Now a days, oxygen and nitrogen containing heterocyclic compounds with medium-ring have attracted considerable interest because of the low reactivity due to transannular strain and a high degree of conformational flexibility. In contrast to the synthesis of five and six membered halolactones, synthesis of medium-sized halolactones and oxepanes are rare. Medium ring size lactones containing 7- to 11-membered rings are the fundamental units of many natural products. For example, Octalactins A is an important naturally occurring 8-membered lactone and was first isolated from actinomycetes of the genus Streptomyces collected from corals of the Mexican coast and exhibit potential cytotoxic activity against melanoma and colon tumor cells.

  

Our current goal is to synthesize nitrogen, oxygen and sulfur containing heterocyclic compounds having biologically activity and fundamental units of many natural products. There are many existing methodologies which provide a range of efficient and selective pathways for the synthesis of nitrogen, oxygen and sulfur containing heterocyclic compounds. The quest for the search of milder catalytic systems with high catalytic activity replacing the traditional metal catalysts still remains an ongoing challenge. As such there is still much interest in the development of new methodologies to address the aforementioned issues towards synthesis of natural products and drug molecules containing these heterocyclic rings.

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Enthusiastically delving into the intricate realm of organic synthesis, my research focuses on Lewis acid mediated intermolecular and intramolecular alkenyl and alkynyl cyclization pathways. These endeavors are aimed at pioneering the synthesis of diverse N- and O- heterocycles, presenting innovative strategies for their construction. Additionally, our work extends to pioneering novel synthetic methodologies tailored for the efficient synthesis of heterocyclic compounds of paramount significance in both biological and pharmaceutical domains. Through meticulous experimentation and inventive design, our efforts strive to push the boundaries of chemical synthesis, contributing to the advancement of science and the betterment of society.